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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4L
All Species:
19.7
Human Site:
S449
Identified Species:
36.11
UniProt:
Q96PU5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96PU5
NP_001138436.1
975
111932
S449
R
R
P
R
S
L
S
S
P
T
V
T
L
S
A
Chimpanzee
Pan troglodytes
XP_001140254
911
104904
P449
R
I
A
P
N
G
R
P
F
F
I
D
H
N
T
Rhesus Macaque
Macaca mulatta
XP_001088661
1010
115306
S484
R
R
P
R
S
L
S
S
P
T
V
T
L
S
A
Dog
Lupus familis
XP_533393
1027
117927
S501
R
R
P
R
S
L
S
S
P
T
V
T
L
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFI0
1004
115400
S478
R
R
P
R
S
L
S
S
P
T
V
T
L
S
A
Rat
Rattus norvegicus
Q62940
887
102376
I443
Q
D
D
P
R
S
K
I
P
A
H
L
R
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
E609
R
Q
I
S
D
E
T
E
I
L
E
N
R
E
S
Chicken
Gallus gallus
XP_424462
1045
119140
S519
R
R
P
R
S
L
S
S
P
T
V
T
L
S
A
Frog
Xenopus laevis
Q2TAS2
751
86306
D327
N
R
T
T
Q
F
T
D
P
R
L
S
A
N
L
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
S341
L
H
L
V
L
N
P
S
P
N
G
S
R
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
E488
Q
Q
H
R
P
S
N
E
D
T
D
H
T
D
S
Honey Bee
Apis mellifera
XP_395191
782
90150
L357
D
L
D
Q
L
G
P
L
P
E
G
W
E
E
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
Q385
I
Q
Q
Q
P
V
S
Q
L
G
P
L
P
S
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.4
92.4
90.8
N.A.
94.3
48
N.A.
43.9
85.6
34.1
34.3
N.A.
47.2
49.4
N.A.
N.A.
Protein Similarity:
100
93.4
93.7
92.2
N.A.
95.6
60
N.A.
54
88.4
49
49.5
N.A.
61.8
61.1
N.A.
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
100
6.6
N.A.
6.6
100
13.3
20
N.A.
13.3
6.6
N.A.
N.A.
P-Site Similarity:
100
26.6
100
100
N.A.
100
13.3
N.A.
26.6
100
40
33.3
N.A.
40
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
37
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
8
0
0
8
8
47
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
16
0
8
0
0
8
8
0
8
8
0
8
0
% D
% Glu:
0
0
0
0
0
8
0
16
0
8
8
0
8
16
0
% E
% Phe:
0
0
0
0
0
8
0
0
8
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
16
0
0
0
8
16
0
0
8
8
% G
% His:
0
8
8
0
0
0
0
0
0
0
8
8
8
0
0
% H
% Ile:
8
8
8
0
0
0
0
8
8
0
8
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% K
% Leu:
8
8
8
0
16
39
0
8
8
8
8
16
39
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
8
8
8
0
0
8
0
8
0
16
0
% N
% Pro:
0
0
39
16
16
0
16
8
70
0
8
0
8
0
0
% P
% Gln:
16
24
8
16
8
0
0
8
0
0
0
0
0
0
0
% Q
% Arg:
54
47
0
47
8
0
8
0
0
8
0
0
24
0
8
% R
% Ser:
0
0
0
8
39
16
47
47
0
0
0
16
0
47
16
% S
% Thr:
0
0
8
8
0
0
16
0
0
47
0
39
8
0
8
% T
% Val:
0
0
0
8
0
8
0
0
0
0
39
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _